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Target
NAD-dependent protein deacetylase sirtuin-1
Ligand
BDBM50376978
Substrate
n/a
Meas. Tech.
ChEMBL_479066 (CHEMBL933817)
EC50
360±n/a nM
Citation
 Milne, JC; Lambert, PD; Schenk, S; Carney, DP; Smith, JJ; Gagne, DJ; Jin, L; Boss, O; Perni, RB; Vu, CB; Bemis, JE; Xie, R; Disch, JS; Ng, PY; Nunes, JJ; Lynch, AV; Yang, H; Galonek, H; Israelian, K; Choy, W; Iffland, A; Lavu, S; Medvedik, O; Sinclair, DA; Olefsky, JM; Jirousek, MR; Elliott, PJ; Westphal, CH Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450:712-716 (2007) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-1
Synonyms:
NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2
Type:
Developmental protein; hydrolase
Mol. Mass.:
81626.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
747
Sequence:
MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS
  
Inhibitor
Name:
BDBM50376978
Synonyms:
CHEMBL403308 | SRT-2183
Type:
Small organic molecule
Emp. Form.:
C27H24N4O2S
Mol. Mass.:
468.57
SMILES:
O[C@@H]1CCN(Cc2csc3nc(cn23)-c2ccccc2NC(=O)c2ccc3ccccc3c2)C1
Structure:
Search PDB for entries with ligand similarity: