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Target
Plasmepsin II
Ligand
BDBM50377588
Substrate
n/a
Meas. Tech.
ChEMBL_479736 (CHEMBL929233)
IC50
0.13±n/a nM
Citation
 Azim, MK; Ahmed, W; Khan, IA; Rao, NA; Khan, KM Identification of acridinyl hydrazides as potent aspartic protease inhibitors. Bioorg Med Chem Lett 18:3011-5 (2008) [PubMed]  Article 
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
  
Inhibitor
Name:
BDBM50377588
Synonyms:
CHEMBL257594
Type:
Small organic molecule
Emp. Form.:
C22H19N3O2
Mol. Mass.:
357.4052
SMILES:
Cc1ccc2c(NNC(=O)c3ccccc3O)c3ccccc3nc2c1C
Structure:
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