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Target
DNA polymerase beta
Ligand
BDBM50260079
Substrate
n/a
Meas. Tech.
ChEMBL_481449 (CHEMBL1008707)
IC50
62800±n/a nM
Citation
 Feng, X; Gao, Z; Li, S; Jones, SH; Hecht, SM DNA polymerase beta lyase inhibitors from Maytenus putterlickoides. J Nat Prod 67:1744-7 (2004) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA Polymerase beta | DPOLB_RAT | Polb
Type:
PROTEIN
Mol. Mass.:
38334.34
Organism:
Rattus norvegicus
Description:
ChEMBL_1361926
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
  
Inhibitor
Name:
BDBM50260079
Synonyms:
30-(4'-hydroxybenzoyloxy)-11alpha-hydroxylupane-20(29)-en-3-one | CHEMBL442814
Type:
Small organic molecule
Emp. Form.:
C37H52O5
Mol. Mass.:
576.8058
SMILES:
C[C@]12CC[C@H]([C@@H]1[C@H]1C[C@@H](O)[C@@H]3[C@@]4(C)CCC(=O)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(=C)COC(=O)c1ccc(O)cc1 |r|
Structure:
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