Reaction Details Report a problem with these data
Target
Myeloblastin
Ligand
BDBM50270031
Substrate
n/a
Meas. Tech.
ChEMBL_508159 (CHEMBL1008217)
IC50
150±n/a nM
Citation
 Méthot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem 282:20836-46 (2007) [PubMed]  Article 
Target
Name:
Myeloblastin
Synonyms:
PRTN3_MOUSE | Prtn3
Type:
PROTEIN
Mol. Mass.:
27628.93
Organism:
Mus musculus
Description:
ChEMBL_508159
Residue:
254
Sequence:
MSGSYPSPKGIHPFLLLALVVGGAVQASKIVGGHEARPHSRPYVASLQLSRFPGSHFCGGTLIHPRFVLTAAHCLQDISWQLVTVVLGAHDLLSSEPEQQKFTISQVFQNNYNPEENLNDVLLLQLNRTASLGKEVAVASLPQQDQTLSQGTQCLAMGWGRLGTQAPTPRVLQELNVTVVTFLCREHNVCTLVPRRAAGICFGDSGGPLICNGILHGVDSFVIRECASLQFPDFFARVSMYVDWIQNVLRGAEP
  
Inhibitor
Name:
BDBM50270031
Synonyms:
1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-fluorothiophen-2-yl)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate | CHEMBL515494
Type:
Small organic molecule
Emp. Form.:
C17H17FN3OS
Mol. Mass.:
330.399
SMILES:
[NH3+]C(Cc1sccc1F)C(=O)N[C@@]1(C[C@@H]1c1ccccc1)C#N |r|
Structure:
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