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Target
Prolyl endopeptidase
Ligand
BDBM50259883
Substrate
n/a
Meas. Tech.
ChEMBL_526176 (CHEMBL973892)
IC50
57430±n/a nM
Citation
 Atta-ur-Rahman, A; Naz, H; Fadimatou, na; Makhmoor, T; Yasin, A; Fatima, N; Ngounou, FN; Kimbu, SF; Sondengam, BL; Choudhary, MI Bioactive constituents from Boswellia papyrifera. J Nat Prod 68:189-93 (2005) [PubMed]  Article 
Target
Name:
Prolyl endopeptidase
Synonyms:
PE | PEP | POP | PPCE_HUMAN | PREP | Post-proline cleaving enzyme | Prolyl oligopeptidase
Type:
Enzyme
Mol. Mass.:
80688.50
Organism:
Homo sapiens (Human)
Description:
P48147
Residue:
710
Sequence:
MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
  
Inhibitor
Name:
BDBM50259883
Synonyms:
CHEMBL449310 | methyl 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oate
Type:
Small organic molecule
Emp. Form.:
C33H52O5
Mol. Mass.:
528.763
SMILES:
COC(=O)[C@@]1(C)[C@@H](CC[C@]2(C)[C@H]3CC[C@@H]4[C@H]5[C@@H](CC[C@]5(C)CC[C@@]4(CO)[C@]3(C)CC[C@@H]12)C(C)=C)OC(C)=O |r|
Structure:
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