Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-6
Ligand
BDBM50034820
Substrate
n/a
Meas. Tech.
ChEMBL_491125 (CHEMBL991893)
Ki
9000±n/a nM
Citation
 Harris, D; Clayton, T; Cook, J; Sahbaie, P; Halliwell, RF; Furtmüller, R; Huck, S; Sieghart, W; DeLorey, TM Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. J Med Chem 51:3788-803 (2008) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-6
Synonyms:
GABA A alpha6 | GABA receptor alpha-6 subunit | GABRA6 | GBRA6_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51029.60
Organism:
Homo sapiens (Human)
Description:
GABA A alpha6 0 HUMAN::Q16445
Residue:
453
Sequence:
MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE
  
Inhibitor
Name:
BDBM50034820
Synonyms:
8-Chloro-3-methoxymethyl-5-methyl-4,5-dihydro-2,5,10b-triaza-benzo[e]azulen-6-one | CHEMBL45346
Type:
Small organic molecule
Emp. Form.:
C14H14ClN3O2
Mol. Mass.:
291.733
SMILES:
COCc1ncn-2c1CN(C)C(=O)c1cc(Cl)ccc-21
Structure:
Search PDB for entries with ligand similarity: