Reaction Details Report a problem with these data
Target
4-hydroxy-tetrahydrodipicolinate synthase
Ligand
BDBM50273975
Substrate
n/a
Meas. Tech.
ChEMBL_536820 (CHEMBL988084)
Ki
830000±n/a nM
Citation
 Boughton, BA; Griffin, MD; O'Donnell, PA; Dobson, RC; Perugini, MA; Gerrard, JA; Hutton, CA Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues. Bioorg Med Chem 16:9975-83 (2008) [PubMed]  Article 
Target
Name:
4-hydroxy-tetrahydrodipicolinate synthase
Synonyms:
DAPA_ECOLI | Dihydrodipicolinate synthase | dapA
Type:
PROTEIN
Mol. Mass.:
31269.12
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_536816
Residue:
292
Sequence:
MFTGSIVAIVTPMDEKGNVCRASLKKLIDYHVASGTSAIVSVGTTGESATLNHDEHADVVMMTLDLADGRIPVIAGTGANATAEAISLTQRFNDSGIVGCLTVTPYYNRPSQEGLYQHFKAIAEHTDLPQILYNVPSRTGCDLLPETVGRLAKVKNIIGIKEATGNLTRVNQIKELVSDDFVLLSGDDASALDFMQLGGHGVISVTANVAARDMAQMCKLAAEGHFAEARVINQRLMPLHNKLFVEPNPIPVKWACKELGLVATDTLRLPMTPITDSGRETVRAALKHAGLL
  
Inhibitor
Name:
BDBM50273975
Synonyms:
2-ketobutyrate | 2-oxobutanate | 2-oxobutanoate | alpha-ketobutyrate | alpha-oxobutyrate
Type:
Small organic molecule
Emp. Form.:
C4H5O3
Mol. Mass.:
101.0812
SMILES:
CCC(=O)C([O-])=O
Structure:
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