Reaction Details Report a problem with these data
Target
4-hydroxy-tetrahydrodipicolinate synthase
Ligand
BDBM50273973
Substrate
n/a
Meas. Tech.
ChEMBL_536821 (CHEMBL988085)
Ki
160000±n/a nM
Citation
 Boughton, BA; Griffin, MD; O'Donnell, PA; Dobson, RC; Perugini, MA; Gerrard, JA; Hutton, CA Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues. Bioorg Med Chem 16:9975-83 (2008) [PubMed]  Article 
Target
Name:
4-hydroxy-tetrahydrodipicolinate synthase
Synonyms:
DAPA_BACSU | Dihydrodipicolinate synthase | dapA
Type:
PROTEIN
Mol. Mass.:
31035.66
Organism:
Bacillus subtilis
Description:
ChEMBL_536821
Residue:
290
Sequence:
MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAGTTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVMLVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVVAIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQMIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLTEDERLSLSSTISEL
  
Inhibitor
Name:
BDBM50273973
Synonyms:
2,6-dioxoheptanedioic acid | CHEMBL451265
Type:
Small organic molecule
Emp. Form.:
C7H8O6
Mol. Mass.:
188.1348
SMILES:
OC(=O)C(=O)CCCC(=O)C(O)=O
Structure:
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