Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50155550
Substrate
n/a
Meas. Tech.
ChEMBL_544671 (CHEMBL1009248)
Ki
3.7±n/a nM
Citation
 Thiry, A; Rolin, S; Vullo, D; Frankart, A; Scozzafava, A; Dogné, JM; Wouters, J; Supuran, CT; Masereel, B Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem 43:2853-60 (2008) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50155550
Synonyms:
2,3,5,6-Tetrafluoro-N-(5-sulfamoyl-indan-2-yl)-benzamide | 2,3,5,6-tetrafluoro-N-(5-sulfamoyl-2,3-dihydro-1H-inden-2-yl)benzamide | CHEMBL186963
Type:
Small organic molecule
Emp. Form.:
C16H12F4N2O3S
Mol. Mass.:
388.337
SMILES:
NS(=O)(=O)c1ccc2CC(Cc2c1)NC(=O)c1c(F)c(F)cc(F)c1F
Structure:
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