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Target
Pro-cathepsin H
Ligand
BDBM50250152
Substrate
n/a
Meas. Tech.
ChEMBL_498768 (CHEMBL1021960)
IC50
145±n/a nM
Citation
 Kang, DH; Jun, KY; Lee, JP; Pak, CS; Na, Y; Kwon, Y Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. J Med Chem 52:3093-7 (2009) [PubMed]  Article 
Target
Name:
Pro-cathepsin H
Synonyms:
CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain
Type:
PROTEIN
Mol. Mass.:
37402.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459870
Residue:
335
Sequence:
MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
  
Inhibitor
Name:
BDBM50250152
Synonyms:
3-acetyl-8-chloro-2-(4-chlorophenylamino)-6-nitroquinolin-4(1H)-one | CHEMBL492175
Type:
Small organic molecule
Emp. Form.:
C17H11Cl2N3O4
Mol. Mass.:
392.193
SMILES:
CC(=O)c1c(Nc2ccc(Cl)cc2)nc2c(Cl)cc(cc2c1O)[N+]([O-])=O
Structure:
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