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Target
Procathepsin L
Ligand
BDBM50304289
Substrate
n/a
Meas. Tech.
ChEMBL_605778 (CHEMBL1074596)
Ki
850±n/a nM
Citation
 Micale, N; Ettari, R; Schirmeister, T; Evers, A; Gelhaus, C; Leippe, M; Zappalà, M; Grasso, S Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors. Bioorg Med Chem 17:6505-11 (2009) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50304289
Synonyms:
1-(4-Methoxyphenyl)-6,7-methylenedioxy-2-(4-methylthiophenyl-ureido)-2H-isoquinolin-3-one | CHEMBL596265
Type:
Small organic molecule
Emp. Form.:
C25H21N3O5S
Mol. Mass.:
475.516
SMILES:
COc1ccc(cc1)-c1n(NC(=O)Nc2ccc(SC)cc2)c(=O)cc2cc3OCOc3cc12
Structure:
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