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Target
Myelin-associated glycoprotein
Ligand
BDBM50378608
Substrate
n/a
Meas. Tech.
ChEMBL_611876 (CHEMBL1070831)
Kd
4100±n/a nM
Citation
 Mesch, S; Moser, D; Strasser, DS; Kelm, A; Cutting, B; Rossato, G; Vedani, A; Koliwer-Brandl, H; Wittwer, M; Rabbani, S; Schwardt, O; Kelm, S; Ernst, B Low molecular weight antagonists of the myelin-associated glycoprotein: synthesis, docking, and biological evaluation. J Med Chem 53:1597-615 (2010) [PubMed]  Article 
Target
Name:
Myelin-associated glycoprotein
Synonyms:
MAG_MOUSE | Mag | Siglec-4a
Type:
PROTEIN
Mol. Mass.:
69368.91
Organism:
Mus musculus
Description:
ChEMBL_663794
Residue:
627
Sequence:
MIFLATLPLFWIMISASRGGHWGAWMPSTISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAKSLYLDLEEVTPGEDGVYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTIRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESSSFSGGDNPHVLYSPEFRISGAPDKYESEKQRLGSERRLLGLRGESPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
  
Inhibitor
Name:
BDBM50378608
Synonyms:
CHEMBL601721
Type:
Small organic molecule
Emp. Form.:
C28H30ClF2N2O9
Mol. Mass.:
611.996
SMILES:
O[C@H](CNC(=O)c1ccc(Cl)cc1)[C@H](O)[C@H]1O[C@@](C[C@@H](O)[C@@H]1NC(=O)CC1CC1)(OCc1cccc(F)c1F)C([O-])=O |r,@@:26|
Structure:
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