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Target
Vitamin D-binding protein
Ligand
BDBM50200182
Substrate
n/a
Meas. Tech.
ChEMBL_622880 (CHEMBL1116619)
Kd
24±n/a nM
Citation
 Sánchez-Abella, L; Fernández, S; Verstuyf, A; Verlinden, L; Gotor, V; Ferrero, M Synthesis, conformational analysis, and biological evaluation of 19-nor-vitamin D3 analogues with A-ring modifications. J Med Chem 52:6158-62 (2009) [PubMed]  Article 
Target
Name:
Vitamin D-binding protein
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
52955.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_622880
Residue:
474
Sequence:
MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPKELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL
  
Inhibitor
Name:
BDBM50200182
Synonyms:
(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol | (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol | (1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol | (5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol | 1,25-DHCC | 1alpha,25(OH)2D3 | 1alpha,25-dihydroxycholecalciferol | 1alpha,25-dihydroxyvitamin D3 | CALCITRIOL | CHEMBL846
Type:
Small organic molecule
Emp. Form.:
C27H44O3
Mol. Mass.:
416.6365
SMILES:
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |r|
Structure:
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