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Target
Prolyl endopeptidase
Ligand
BDBM50316827
Substrate
n/a
Meas. Tech.
ChEMBL_632258 (CHEMBL1110120)
Ki
70000±n/a nM
Citation
 Lawandi, J; Gerber-Lemaire, S; Juillerat-Jeanneret, L; Moitessier, N Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors. J Med Chem 53:3423-38 (2010) [PubMed]  Article 
Target
Name:
Prolyl endopeptidase
Synonyms:
PE | PPCE_BOVIN | PREP | Post-proline cleaving enzyme
Type:
PROTEIN
Mol. Mass.:
80630.39
Organism:
Bos taurus
Description:
ChEMBL_632258
Residue:
710
Sequence:
MLSFQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCNFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVCLDPNTLSDDGTVALRGYAFSEDGEYVAYGLSASGSDWVTIKFMKVDGAKELADVLERVKFSCMAWTHDGKGMFYNAYPQQDGKSDGTETSTNLHQKLCYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLHQEPNGITGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRHSPNYRLINIDFTDPEESRWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNTLQLHDMATGALLKTFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVCRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDNKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSPKFIATLQHLVGRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIQ
  
Inhibitor
Name:
BDBM50316827
Synonyms:
(S)-benzyl 2-(2-(2-chloroacetyl)pyrrolidin-1-yl)-2-oxoethylcarbamate | CHEMBL1087483
Type:
Small organic molecule
Emp. Form.:
C16H19ClN2O4
Mol. Mass.:
338.786
SMILES:
ClCC(=O)[C@@H]1CCCN1C(=O)CNC(=O)OCc1ccccc1 |r|
Structure:
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