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Target
Geranylgeranyl pyrophosphate synthase
Ligand
BDBM25308
Substrate
n/a
Meas. Tech.
ChEMBL_631184 (CHEMBL1110033)
IC50
670±n/a nM
Citation
 McKenna, CE; Kashemirov, BA; Blazewska, KM; Mallard-Favier, I; Stewart, CA; Rojas, J; Lundy, MW; Ebetino, FH; Baron, RA; Dunford, JE; Kirsten, ML; Seabra, MC; Bala, JL; Marma, MS; Rogers, MJ; Coxon, FP Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med Chem 53:3454-64 (2010) [PubMed]  Article 
Target
Name:
Geranylgeranyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase
Type:
Homooctamer; transferase
Mol. Mass.:
34867.94
Organism:
Homo sapiens (Human)
Description:
Recombinant human GGPPS was cloned and expressed in E. coli.
Residue:
300
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
  
Inhibitor
Name:
BDBM25308
Synonyms:
(1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosphonoethyl)phosphonic acid | bisphosphonate, 57
Type:
Small organic molecule
Emp. Form.:
C9H12N2O7P2
Mol. Mass.:
322.1483
SMILES:
OC(Cc1cnc2ccccn12)(P(O)(O)=O)P(O)(O)=O
Structure:
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