Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50293031
Substrate
n/a
Meas. Tech.
ChEMBL_629506 (CHEMBL1120795)
Ki
120±n/a nM
Citation
 Taliani, S; La Motta, C; Mugnaini, L; Simorini, F; Salerno, S; Marini, AM; Da Settimo, F; Cosconati, S; Cosimelli, B; Greco, G; Limongelli, V; Marinelli, L; Novellino, E; Ciampi, O; Daniele, S; Trincavelli, ML; Martini, C Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation. J Med Chem 53:3954-63 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50293031
Synonyms:
2-chloro-N6-(3-iodobenzyl)-5'-N-methylcarbamoyladenosine | 2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide | CHEMBL515442
Type:
Small organic molecule
Emp. Form.:
C19H20ClIN6O5
Mol. Mass.:
574.757
SMILES:
CNC(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12 |r|
Structure:
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