Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50318282
Substrate
n/a
Meas. Tech.
ChEMBL_629508 (CHEMBL1120797)
Ki
120.8±n/a nM
Citation
 Taliani, S; La Motta, C; Mugnaini, L; Simorini, F; Salerno, S; Marini, AM; Da Settimo, F; Cosconati, S; Cosimelli, B; Greco, G; Limongelli, V; Marinelli, L; Novellino, E; Ciampi, O; Daniele, S; Trincavelli, ML; Martini, C Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation. J Med Chem 53:3954-63 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50318282
Synonyms:
1-(2-benzyl-6-phenyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-(3-chlorophenyl)urea | CHEMBL1097736
Type:
Small organic molecule
Emp. Form.:
C25H19ClN6O
Mol. Mass.:
454.911
SMILES:
Clc1cccc(NC(=O)Nc2nc(nc3nn(Cc4ccccc4)cc23)-c2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: