Reaction Details Report a problem with these data
Target
Lysosomal acid lipase/cholesteryl ester hydrolase
Ligand
BDBM50318692
Substrate
n/a
Meas. Tech.
ChEMBL_633497 (CHEMBL1119694)
IC50
473±n/a nM
Citation
 Rosenbaum, AI; Cosner, CC; Mariani, CJ; Maxfield, FR; Wiest, O; Helquist, P Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J Med Chem 53:5281-9 (2010) [PubMed]  Article 
Target
Name:
Lysosomal acid lipase/cholesteryl ester hydrolase
Synonyms:
LICH_HUMAN | LIPA
Type:
PROTEIN
Mol. Mass.:
45422.01
Organism:
Homo sapiens (Human)
Description:
ChEMBL_633497
Residue:
399
Sequence:
MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQITNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ
  
Inhibitor
Name:
BDBM50318692
Synonyms:
4-(Pyrrolidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate | CHEMBL1085856
Type:
Small organic molecule
Emp. Form.:
C11H16N4O3S
Mol. Mass.:
284.335
SMILES:
O=C(Oc1nsnc1N1CCCC1)N1CCOCC1
Structure:
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