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Target
Histone deacetylase 8
Ligand
BDBM50321385
Substrate
n/a
Meas. Tech.
ChEMBL_640313 (CHEMBL1174638)
IC50
43160±n/a nM
Citation
 Chetan, B; Bunha, M; Jagrat, M; Sinha, BN; Saiko, P; Graser, G; Szekeres, T; Raman, G; Rajendran, P; Moorthy, D; Basu, A; Jayaprakash, V Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity. Bioorg Med Chem Lett 20:3906-10 (2010) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50321385
Synonyms:
4-(2-(4-chlorobenzylidene)hydrazinecarbonothioyl)-N-hydroxypiperazine-1-carboxamide | CHEMBL1171228
Type:
Small organic molecule
Emp. Form.:
C13H16ClN5O2S
Mol. Mass.:
341.816
SMILES:
ONC(=O)N1CCN(CC1)C(=S)NN=Cc1ccc(Cl)cc1 |w:14.15|
Structure:
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