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Target
Cyclin-dependent kinase 2
Ligand
BDBM50321578
Substrate
n/a
Meas. Tech.
ChEMBL_639725 (CHEMBL1175614)
IC50
10±n/a nM
Citation
 Angiolini, M; Banfi, P; Casale, E; Casuscelli, F; Fiorelli, C; Saccardo, MB; Silvagni, M; Zuccotto, F Structure-based optimization of potent PDK1 inhibitors. Bioorg Med Chem Lett 20:4095-9 (2010) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50321578
Synonyms:
1-(2-amino-2-oxoethyl)-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | CHEMBL1171948
Type:
Small organic molecule
Emp. Form.:
C18H17N7O2
Mol. Mass.:
363.3733
SMILES:
NC(=O)Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4)nc3-c12
Structure:
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