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Target
Ribosyldihydronicotinamide dehydrogenase [quinone]
Ligand
BDBM50131692
Substrate
n/a
Meas. Tech.
ChEMBL_642470 (CHEMBL1175843)
IC50
1700±n/a nM
Citation
 Sun, B; Hoshino, J; Jermihov, K; Marler, L; Pezzuto, JM; Mesecar, AD; Cushman, M Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem 18:5352-66 (2010) [PubMed]  Article 
Target
Name:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Synonyms:
Metallothionein-3 | NMOR2 | NQO2 | NQO2_HUMAN | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone]
Type:
Protein
Mol. Mass.:
25917.25
Organism:
Homo sapiens (Human)
Description:
P16083
Residue:
231
Sequence:
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
  
Inhibitor
Name:
BDBM50131692
Synonyms:
3,5-Dimethoxy-4'-amino-trans-stilbene | 4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenylamine | CHEMBL324290 | trans-3,5-dimethoxyl-4'-aminostilbene
Type:
Small organic molecule
Emp. Form.:
C16H17NO2
Mol. Mass.:
255.3117
SMILES:
COc1cc(OC)cc(\C=C\c2ccc(N)cc2)c1
Structure:
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