Reaction Details Report a problem with these data
Target
Sodium/glucose cotransporter 1
Ligand
BDBM50335143
Substrate
n/a
Meas. Tech.
ChEMBL_702890 (CHEMBL1655515)
EC50
461.6±n/a nM
Citation
 Chang, CC; Chao, YS; Chen, CT; Chiu, CH; Chu, KF; Hsiao, WC; Hsieh, CJ; Yuan, MC; Hsieh, TC; Huang, CY; Hung, MS; Lee, JC; Liu, YW; Song, JS; Tsai, CH; Wang, MH; Wu, SH; Yao, CH; Yeh, TK Discovery of novel N-ß-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes. J Med Chem 54:166-78 (2011) [PubMed]  Article 
Target
Name:
Sodium/glucose cotransporter 1
Synonyms:
High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1
Type:
Protein
Mol. Mass.:
73503.78
Organism:
Homo sapiens (Human)
Description:
P13866
Residue:
664
Sequence:
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA
  
Inhibitor
Name:
BDBM50335143
Synonyms:
4-Chloro-3-[4-(methylsulfanyl)benzyl]-1-(beta-D-xylopyranosyl)-1H-indole | CHEMBL1650499
Type:
Small organic molecule
Emp. Form.:
C21H22ClNO4S
Mol. Mass.:
419.922
SMILES:
CSc1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: