Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase D1
Ligand
BDBM50336963
Substrate
n/a
Meas. Tech.
ChEMBL_718964 (CHEMBL1681586)
IC50
193±n/a nM
Citation
 Bravo-Altamirano, K; George, KM; Frantz, MC; Lavalle, CR; Tandon, M; Leimgruber, S; Sharlow, ER; Lazo, JS; Wang, QJ; Wipf, P Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D. ACS Med Chem Lett 2:154-159 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase D1
Synonyms:
KPCD1_HUMAN | PKD | PKD1 | PRKCM | PRKD1 | Protein kinase C mu | Protein kinase C mu type | Protein kinase C mu type (PRKD1) | Protein kinase C, PKC; classical/novel | Protein kinase D | Protein kinase D (PRKD1) | Serine/threonine-protein kinase D1 (PKD1) | nPKC-D1 | nPKC-mu
Type:
Serine/threonine-protein kinase
Mol. Mass.:
101705.07
Organism:
Homo sapiens (Human)
Description:
gi_115529463
Residue:
912
Sequence:
MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL
  
Inhibitor
Name:
BDBM50336963
Synonyms:
2,3,4,5-Tetrahydro-10-methoxybenzo[b]thieno[2,3-f]-1,5-thiazocin-6-one | CHEMBL1672574 | kb-NB184-02
Type:
Small organic molecule
Emp. Form.:
C13H13NO2S2
Mol. Mass.:
279.378
SMILES:
COc1ccc2sc3c(SCCCNC3=O)c2c1
Structure:
Search PDB for entries with ligand similarity: