Reaction Details Report a problem with these data
Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM50341905
Substrate
n/a
Meas. Tech.
ChEMBL_743289 (CHEMBL1767488)
Ki
37000±n/a nM
Citation
 Lewis, M; Meza-Avina, ME; Wei, L; Crandall, IE; Bello, AM; Poduch, E; Liu, Y; Paige, CJ; Kain, KC; Pai, EF; Kotra, LP Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase. J Med Chem 54:2891-901 (2011) [PubMed]  Article 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
OMP decarboxylase | OMPDCase | Orotidine 5-phosphate decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase) | PYRF_METTH | pyrF
Type:
Enzyme
Mol. Mass.:
24909.45
Organism:
Methanobacterium thermoautotrophicum
Description:
n/a
Residue:
228
Sequence:
MRSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFRKRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDLLNP
  
Inhibitor
Name:
BDBM50341905
Synonyms:
CHEMBL1765124 | ammonium 6-Cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-Monophosphate
Type:
Small organic molecule
Emp. Form.:
C10H9FN3O7P
Mol. Mass.:
333.1676
SMILES:
O[C@@H]1[C@@H](CP([O-])([O-])=O)O[C@H]([C@@H]1F)n1c(cc(=O)[nH]c1=O)C#N |r|
Structure:
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