Reaction Details Report a problem with these data
Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM50341906
Substrate
n/a
Meas. Tech.
ChEMBL_743289 (CHEMBL1767488)
Ki
3322000±n/a nM
Citation
 Lewis, M; Meza-Avina, ME; Wei, L; Crandall, IE; Bello, AM; Poduch, E; Liu, Y; Paige, CJ; Kain, KC; Pai, EF; Kotra, LP Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase. J Med Chem 54:2891-901 (2011) [PubMed]  Article 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
OMP decarboxylase | OMPDCase | Orotidine 5-phosphate decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase) | PYRF_METTH | pyrF
Type:
Enzyme
Mol. Mass.:
24909.45
Organism:
Methanobacterium thermoautotrophicum
Description:
n/a
Residue:
228
Sequence:
MRSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFRKRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDLLNP
  
Inhibitor
Name:
BDBM50341906
Synonyms:
Ammonium 6-Amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-Monophosphate | CHEMBL1765121
Type:
Small organic molecule
Emp. Form.:
C10H11FN3O8P
Mol. Mass.:
351.1829
SMILES:
NC(=O)c1cc(=O)[nH]c(=O)n1[C@@H]1O[C@H](CP([O-])([O-])=O)[C@@H](O)[C@H]1F |r|
Structure:
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