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Target
Caspase-1
Ligand
BDBM50379299
Substrate
n/a
Meas. Tech.
ChEMBL_811620 (CHEMBL2014073)
IC50
100000±n/a nM
Citation
 Stierle, DB; Stierle, AA; Girtsman, T; McIntyre, K; Nichols, J Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum. J Nat Prod 75:262-6 (2012) [PubMed]  Article 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM50379299
Synonyms:
CHEMBL2011679
Type:
Small organic molecule
Emp. Form.:
C22H33NO5
Mol. Mass.:
391.5011
SMILES:
CC(C)[C@H](NC(C)=O)C(=O)O[C@H]1CCC(C)(C)[C@@H]2CC=C3[C@H](COC3=O)[C@@]12C |r,c:19|
Structure:
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