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Target
ATP-dependent RNA helicase DDX1
Ligand
BDBM50379304
Substrate
n/a
Meas. Tech.
ChEMBL_811952 (CHEMBL2013322)
IC50
>500000±n/a nM
Citation
 Radi, M; Falchi, F; Garbelli, A; Samuele, A; Bernardo, V; Paolucci, S; Baldanti, F; Schenone, S; Manetti, F; Maga, G; Botta, M Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors. Bioorg Med Chem Lett 22:2094-8 (2012) [PubMed]  Article 
Target
Name:
ATP-dependent RNA helicase DDX1
Synonyms:
DBP-RB | DDX1 | DDX1_HUMAN | DEAD box protein 1 | DEAD box protein retinoblastoma
Type:
PROTEIN
Mol. Mass.:
82440.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_811952
Residue:
740
Sequence:
MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATKGLMKGKHYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGSYKGHVDILAPTVQELAALEKEAQTSFLHLGYLPNQLFRTF
  
Inhibitor
Name:
BDBM50379304
Synonyms:
CHEMBL2011805
Type:
Small organic molecule
Emp. Form.:
C22H15N3O2
Mol. Mass.:
353.3734
SMILES:
O=C(Nc1ccc(cc1)-c1nc2ccccc2[nH]1)c1cc2ccccc2o1
Structure:
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