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Target
Plasminogen
Ligand
BDBM50380628
Substrate
n/a
Meas. Tech.
ChEMBL_813172 (CHEMBL2020838)
Ki
530±n/a nM
Citation
 Saupe, SM; Steinmetzer, T A new strategy for the development of highly potent and selective plasmin inhibitors. J Med Chem 55:1171-80 (2012) [PubMed]  Article 
Target
Name:
Plasminogen
Synonyms:
Activation peptide | Angiostatin | PLG | PLMN_HUMAN | Plasmin | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B
Type:
Enzyme
Mol. Mass.:
90579.18
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
810
Sequence:
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
  
Inhibitor
Name:
BDBM50380628
Synonyms:
CHEMBL2016876
Type:
Small organic molecule
Emp. Form.:
C31H46N4O3
Mol. Mass.:
522.7219
SMILES:
CCCCCCCCNC(=O)[C@@H](Cc1ccc(OCc2ccncc2)cc1)NC(=O)[C@H]1CC[C@H](CN)CC1 |r,wU:11.28,33.35,wD:30.31,(18.44,-28.09,;19.77,-28.86,;21.11,-28.09,;22.44,-28.86,;23.77,-28.09,;25.11,-28.86,;26.44,-28.09,;27.77,-28.86,;29.11,-28.09,;30.44,-28.86,;30.44,-30.4,;31.78,-28.09,;31.78,-26.55,;30.44,-25.78,;30.45,-24.24,;29.11,-23.47,;27.78,-24.24,;26.44,-23.47,;25.11,-24.25,;23.78,-23.48,;23.78,-21.94,;22.45,-21.17,;21.11,-21.94,;21.12,-23.49,;22.45,-24.25,;27.78,-25.79,;29.12,-26.55,;33.11,-28.86,;34.44,-28.09,;34.44,-26.55,;35.78,-28.86,;35.77,-30.4,;37.09,-31.17,;38.43,-30.4,;39.76,-31.18,;39.75,-32.72,;38.43,-28.86,;37.1,-28.08,)|
Structure:
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