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Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50381011
Substrate
n/a
Meas. Tech.
ChEMBL_814117 (CHEMBL2020711)
IC50
10360±n/a nM
Citation
 Liu, C; Jin, J; Chen, L; Zhou, J; Chen, X; Fu, D; Song, H; Xu, B Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton. Bioorg Med Chem 20:2992-9 (2012) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
  
Inhibitor
Name:
BDBM50381011
Synonyms:
CHEMBL2017127
Type:
Small organic molecule
Emp. Form.:
C25H17FN2O6S
Mol. Mass.:
492.476
SMILES:
COc1ccc(cc1F)C(=O)c1cc(NC(=O)c2cc3ccccc3s2)ccc1NC(=O)C(O)=O
Structure:
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