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Target
Hexokinase-4
Ligand
BDBM50381632
Substrate
n/a
Meas. Tech.
ChEMBL_815664 (CHEMBL2025594)
EC50
242±n/a nM
Citation
 Mao, W; Ning, M; Liu, Z; Zhu, Q; Leng, Y; Zhang, A Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators. Bioorg Med Chem 20:2982-91 (2012) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50381632
Synonyms:
CHEMBL2023435
Type:
Small organic molecule
Emp. Form.:
C28H32N4O6S
Mol. Mass.:
552.642
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#8]-c1cc(-[#8]-c2ccc(cc2)S(=O)(=O)[#7]-2-[#6]-[#6]-3-[#6]-[#6]-[#6](-[#6]-2)-[#8]-3)cc(c1)-[#6](=O)-[#7]-c1ccn(-[#6])n1
Structure:
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