Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50381873
Substrate
n/a
Meas. Tech.
ChEMBL_817533 (CHEMBL2027756)
Ki
70±n/a nM
Citation
 Manera, C; Saccomanni, G; Malfitano, AM; Bertini, S; Castelli, F; Laezza, C; Ligresti, A; Lucchesi, V; Tuccinardi, T; Rizzolio, F; Bifulco, M; Di Marzo, V; Giordano, A; Macchia, M; Martinelli, A Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold. Eur J Med Chem 52:284-94 (2012) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50381873
Synonyms:
CHEMBL2022696
Type:
Small organic molecule
Emp. Form.:
C19H21FN2O2
Mol. Mass.:
328.3806
SMILES:
Fc1ccc(Cn2cccc(C(=O)NC3CCCCC3)c2=O)cc1
Structure:
Search PDB for entries with ligand similarity: