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Target
Renin
Ligand
BDBM50382335
Substrate
n/a
Meas. Tech.
ChEMBL_817422 (CHEMBL2027645)
IC50
0.27±n/a nM
Citation
 Jia, L; Simpson, RD; Yuan, J; Xu, Z; Zhao, W; Cacatian, S; Tice, CM; Guo, J; Ishchenko, A; Singh, SB; Wu, Z; McKeever, BM; Bukhtiyarov, Y; Johnson, JA; Doe, CP; Harrison, RK; McGeehan, GM; Dillard, LW; Baldwin, JJ; Claremon, DA Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. ACS Med Chem Lett 2:747-751 (2011) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50382335
Synonyms:
CHEMBL2024249
Type:
Small organic molecule
Emp. Form.:
C27H43ClFN3O3
Mol. Mass.:
512.1
SMILES:
COCCCC[C@](O)([C@@H]1CCCN(C1)C(=O)NC[C@@H](N)CC1CCCCC1)c1cccc(Cl)c1F |r|
Structure:
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