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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50383437
Substrate
n/a
Meas. Tech.
ChEMBL_818260 (CHEMBL2034221)
IC50
41±n/a nM
Citation
 Graham, TH; Liu, W; Verras, A; Reibarkh, M; Bleasby, K; Bhatt, UR; Chen, Q; Garcia-Calvo, M; Geissler, WM; Gorski, JN; He, H; Lassman, ME; Lisnock, J; Li, X; Shen, Z; Tong, X; Tung, EC; Wiltsie, J; Xie, D; Xu, S; Xiao, J; Hale, JJ; Pinto, S; Shen, DM A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes. Bioorg Med Chem Lett 22:2818-22 (2012) [PubMed]  Article 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase
Type:
PROTEIN
Mol. Mass.:
55028.96
Organism:
Mus musculus
Description:
ChEMBL_1335505
Residue:
491
Sequence:
MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGFADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLPAWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNIIFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMKKWILDFYSNIQ
  
Inhibitor
Name:
BDBM50383437
Synonyms:
CHEMBL2031367
Type:
Small organic molecule
Emp. Form.:
C29H34ClF2N5O
Mol. Mass.:
542.063
SMILES:
CN(C)[C@@H]1C[C@H]([C@@H](C1)c1ccc(F)cc1F)C(=O)N1CCC(CC1)c1nc(C)nn1-c1ccc(Cl)c(C)c1 |r|
Structure:
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