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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50384347
Substrate
n/a
Meas. Tech.
ChEMBL_818176 (CHEMBL2033953)
IC50
15±n/a nM
Citation
 Perez, HL; Banfi, P; Bertrand, J; Cai, ZW; Grebinski, JW; Kim, K; Lippy, J; Modugno, M; Naglich, J; Schmidt, RJ; Tebben, A; Vianello, P; Wei, DD; Zhang, L; Galvani, A; Lombardo, LJ; Borzilleri, RM Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists. Bioorg Med Chem Lett 22:3946-50 (2012) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50384347
Synonyms:
CHEMBL2031016
Type:
Small organic molecule
Emp. Form.:
C48H48ClN5O8S
Mol. Mass.:
890.441
SMILES:
CCCCN(CCCC)C(=O)c1nn(c(C)c1Cl)-c1ccc(cc1C(=O)N1CCc2ccccc2C1)C(=O)NS(=O)(=O)c1ccc2cccc(OCc3ccc(cc3)C(O)=O)c2c1
Structure:
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