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Target
Bcl-2-like protein 1
Ligand
BDBM50384352
Substrate
n/a
Meas. Tech.
ChEMBL_818177 (CHEMBL2033954)
IC50
17±n/a nM
Citation
 Perez, HL; Banfi, P; Bertrand, J; Cai, ZW; Grebinski, JW; Kim, K; Lippy, J; Modugno, M; Naglich, J; Schmidt, RJ; Tebben, A; Vianello, P; Wei, DD; Zhang, L; Galvani, A; Lombardo, LJ; Borzilleri, RM Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists. Bioorg Med Chem Lett 22:3946-50 (2012) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50384352
Synonyms:
CHEMBL2031021 | US9346795, 53
Type:
Small organic molecule
Emp. Form.:
C40H47ClN6O5S
Mol. Mass.:
759.356
SMILES:
CCCCN(CCCC)C(=O)c1nn(c(C)c1Cl)-c1ccc(cc1C(=O)N1CCc2ccccc2C1)C(=O)NS(=O)(=O)c1ccc2N(CC)CCc2c1
Structure:
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