Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50387397
Substrate
n/a
Meas. Tech.
ChEMBL_828203 (CHEMBL2050135)
Ki
2340±n/a nM
Citation
 Tu, Z; Wang, W; Cui, J; Zhang, X; Lu, X; Xu, J; Parsons, SM Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups. Bioorg Med Chem 20:4422-9 (2012) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50387397
Synonyms:
CHEMBL2047240
Type:
Small organic molecule
Emp. Form.:
C24H30N2O4S
Mol. Mass.:
442.571
SMILES:
COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(C[C@H]1O)C(=O)c1ccc(C)s1 |r|
Structure:
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