Target
Aurora kinase B
Ligand
BDBM50389981
Substrate
n/a
Meas. Tech.
ChEMBL_835007 (CHEMBL2073499)
IC50
16±n/a nM
Citation
 Curtin, MLHeyman, HRFrey, RRMarcotte, PAGlaser, KBJankowski, JRMagoc, TJAlbert, DHOlson, AMReuter, DRBouska, JJMontgomery, DAPalma, JPDonawho, CKStewart, KDTse, CMichaelides, MR Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases. Bioorg Med Chem Lett 22:4750-5 (2012) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50389981
Synonyms:
CHEMBL2071209
Type:
Small organic molecule
Emp. Form.:
C16H14F3N7O
Mol. Mass.:
377.3239
SMILES:
Cn1cc(Nc2ncc(c(Nc3ccccc3C(N)=O)n2)C(F)(F)F)cn1
Structure:
Search PDB for entries with ligand similarity: