Reaction Details Report a problem with these data
Target
P2Y purinoceptor 1
Ligand
BDBM59704
Substrate
n/a
Meas. Tech.
ChEMBL_833986 (CHEMBL2072726)
IC50
140±n/a nM
Citation
 Costanzi, S; Santhosh Kumar, T; Balasubramanian, R; Kendall Harden, T; Jacobson, KA Virtual screening leads to the discovery of novel non-nucleotide P2Y1 receptor antagonists. Bioorg Med Chem 20:5254-61 (2012) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 1
Synonyms:
ATP receptor | P2RY1 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2Y1) | P2Y1 | Purinergic receptor | Purinergic receptor P2Y1
Type:
Enzyme
Mol. Mass.:
42090.25
Organism:
Homo sapiens (Human)
Description:
P47900
Residue:
373
Sequence:
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL
  
Inhibitor
Name:
BDBM59704
Synonyms:
1-(3,4-dichlorophenyl)-3-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]urea | 1-(3,4-dichlorophenyl)-3-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]urea | 1-(3,4-dichlorophenyl)-3-[4-[(3,4-dimethylisoxazol-5-yl)sulfamoyl]phenyl]urea | 4-({[(3,4-dichlorophenyl)amino]carbonyl}amino)-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide | MLS000050956 | SMR000078689 | cid_1188014
Type:
Small organic molecule
Emp. Form.:
C18H16Cl2N4O4S
Mol. Mass.:
455.315
SMILES:
Cc1noc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(Cl)c(Cl)c3)cc2)c1C
Structure:
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