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Target
Inward rectifier potassium channel 2
Ligand
BDBM50391770
Substrate
n/a
Meas. Tech.
ChEMBL_849883 (CHEMBL2148627)
IC50
>100000±n/a nM
Citation
 Tang, H; Walsh, SP; Yan, Y; de Jesus, RK; Shahripour, A; Teumelsan, N; Zhu, Y; Ha, S; Owens, KA; Thomas-Fowlkes, BS; Felix, JP; Liu, J; Kohler, M; Priest, BT; Bailey, T; Brochu, R; Alonso-Galicia, M; Kaczorowski, GJ; Roy, S; Yang, L; Mills, SG; Garcia, ML; Pasternak, A Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics. ACS Med Chem Lett 3:367-372 (2012) [PubMed]  Article 
Target
Name:
Inward rectifier potassium channel 2
Synonyms:
Cardiac inward rectifier potassium channel | IRK-1 | IRK1 | Inward rectifier K(+) channel Kir2.1 | KCNJ2 | KCNJ2_HUMAN | Potassium channel, inwardly rectifying subfamily J member 2 | hIRK1
Type:
PROTEIN
Mol. Mass.:
48281.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515520
Residue:
427
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI
  
Inhibitor
Name:
BDBM50391770
Synonyms:
CHEMBL2146755 | US9073882, 1
Type:
Small organic molecule
Emp. Form.:
C20H24N4O4
Mol. Mass.:
384.429
SMILES:
[O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(cc3)[N+]([O-])=O)CC2)cc1
Structure:
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