Reaction Details Report a problem with these data
Target
Microsomal triglyceride transfer protein large subunit
Ligand
BDBM50391858
Substrate
n/a
Meas. Tech.
ChEMBL_849012 (CHEMBL2150038)
IC50
0.001±n/a nM
Citation
 Robinson, RP; Bartlett, JA; Bertinato, P; Bessire, AJ; Cosgrove, J; Foley, PM; Manion, TB; Minich, ML; Ramos, B; Reese, MR; Schmahai, TJ; Swick, AG; Tess, DA; Vaz, A; Wolford, A Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. Bioorg Med Chem Lett 21:4150-4 (2011) [PubMed]  Article 
Target
Name:
Microsomal triglyceride transfer protein large subunit
Synonyms:
MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit
Type:
PROTEIN
Mol. Mass.:
99365.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_971724
Residue:
894
Sequence:
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
  
Inhibitor
Name:
BDBM50391858
Synonyms:
CHEMBL2147281
Type:
Small organic molecule
Emp. Form.:
C40H30F4N4O3
Mol. Mass.:
690.6848
SMILES:
CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2c1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: