Reaction Details Report a problem with these data
Target
Neutral ceramidase
Ligand
BDBM50392472
Substrate
n/a
Meas. Tech.
ChEMBL_852173 (CHEMBL2157594)
IC50
120000±n/a nM
Citation
 Bhabak, KP; Arenz, C Novel amide- and sulfonamide-based aromatic ethanolamines: effects of various substituents on the inhibition of acid and neutral ceramidases. Bioorg Med Chem 20:6162-70 (2012) [PubMed]  Article 
Target
Name:
Neutral ceramidase
Synonyms:
ASAH2 | ASAH2_HUMAN | Acylsphingosine deacylase 2 | BCDase | HNAC1 | LCDase | N-CDase | N-acylsphingosine amidohydrolase 2 | NCDase | Neutral ceramidase soluble form | Non-lysosomal ceramidase | hCD
Type:
PROTEIN
Mol. Mass.:
85523.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_947546
Residue:
780
Sequence:
MAKRTFSNLETFLIFLLVMMSAITVALLSLLFITSGTIENHKDLGGHFFSTTQSPPATQGSTAAQRSTATQHSTATQSSTATQTSPVPLTPESPLFQNFSGYHIGVGRADCTGQVADINLMGYGKSGQNAQGILTRLYSRAFIMAEPDGSNRTVFVSIDIGMVSQRLRLEVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHMVTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIVLKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVAAFASSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRAMYQRAKELYASASQEVTGPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAAGTIDGVGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVDVQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIPSIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQTHQTFLTVEKYEATSTSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPAVILSFEGTSPAFEVVTI
  
Inhibitor
Name:
BDBM50392472
Synonyms:
CHEMBL408217
Type:
Small organic molecule
Emp. Form.:
C23H38N2O5
Mol. Mass.:
422.5582
SMILES:
CCCCCCCCCCCCCC(=O)N[C@H](CO)[C@H](O)c1ccc(cc1)[N+]([O-])=O |r|
Structure:
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