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Target
Neutrophil collagenase
Ligand
BDBM50392684
Substrate
n/a
Meas. Tech.
ChEMBL_854274 (CHEMBL2154440)
IC50
4500±n/a nM
Citation
 Nicolotti, O; Catto, M; Giangreco, I; Barletta, M; Leonetti, F; Stefanachi, A; Pisani, L; Cellamare, S; Tortorella, P; Loiodice, F; Carotti, A Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9. Eur J Med Chem 58:368-76 (2012) [PubMed]  Article 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50392684
Synonyms:
CHEMBL2151353
Type:
Small organic molecule
Emp. Form.:
C18H13ClN2O5
Mol. Mass.:
372.759
SMILES:
OC1(CC(=O)c2ccc(cc2)-c2cccc(Cl)c2)C(=O)NC(=O)NC1=O
Structure:
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