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Target
Dual specificity protein phosphatase 2
Ligand
BDBM50360601
Substrate
n/a
Meas. Tech.
ChEMBL_857252 (CHEMBL2160597)
IC50
9200±n/a nM
Citation
 Xiong, Y; Guo, J; Candelore, MR; Liang, R; Miller, C; Dallas-Yang, Q; Jiang, G; McCann, PE; Qureshi, SA; Tong, X; Xu, SS; Shang, J; Vincent, SH; Tota, LM; Wright, MJ; Yang, X; Zhang, BB; Tata, JR; Parmee, ER Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-ß-alanine (MK-0893) for the treatment of type II diabetes. J Med Chem 55:6137-48 (2012) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 2
Synonyms:
DUS2_HUMAN | DUSP2 | Dual specificity protein phosphatase PAC-1 | PAC1
Type:
PROTEIN
Mol. Mass.:
34405.82
Organism:
Homo sapiens (Human)
Description:
ChEMBL_857252
Residue:
314
Sequence:
MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRARGPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRAGPTAVYFLRGGFDGFQGCCPDLCSEAPAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLCH
  
Inhibitor
Name:
BDBM50360601
Synonyms:
CHEMBL1933349 | MK-0893
Type:
Small organic molecule
Emp. Form.:
C32H27Cl2N3O4
Mol. Mass.:
588.48
SMILES:
COc1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1 |r|
Structure:
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