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Target
Lysosomal alpha-glucosidase
Ligand
BDBM50394348
Substrate
n/a
Meas. Tech.
ChEMBL_857276 (CHEMBL2160771)
IC50
>236000±n/a nM
Citation
 Tanabe, G; Matsuoka, K; Yoshinaga, M; Xie, W; Tsutsui, N; A Amer, MF; Nakamura, S; Nakanishi, I; Wu, X; Yoshikawa, M; Muraoka, O Role of the side chain stereochemistry in thea-glucosidase inhibitory activity of kotalanol, a potent naturala-glucosidase inhibitor. Part 2. Bioorg Med Chem 20:6321-34 (2012) [PubMed]  Article 
Target
Name:
Lysosomal alpha-glucosidase
Synonyms:
Acidic alpha-glucosidase | Gaa | LYAG_RAT
Type:
PROTEIN
Mol. Mass.:
106191.24
Organism:
Rattus norvegicus
Description:
ChEMBL_1506157
Residue:
953
Sequence:
MNIRKPLCSNSVVGACTLVSLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQESYEPAPLHIQEHAEQLRAVPTQCDVTPNSRFDCAPDKGITQEQCEARGCCWVPAGQVLNGPVMGQPWCFFPPSYPSYRLENLSSTESGYTATLTRTSPTFFPKDVLTLQLEVLMETDSRLHFMIKDPTSKRYEVPLETPRVLSQAPSPLYSVEFSEEPFGVIVRRKLGGRVLLNTTVAPLFFADQFLQLSTSLPSQHIAGLGEHLSPLMLSTEWTRITLWNRDVAPSQGVNLYGSHPFYLALEDGGLAHGVFLLNSNAMDVVLQPSPALTWRSTGGILDVYVFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFPLDVQWNDLDYMDARRDFTFNQDGFADFPDMVHELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPETLDWWQDMVSEFHAQVPFDGMWIDMNEPSNFIRGSQQGCPDNELENPPYVPGVVGGALQAATICASSHQFLSTHYNLHNLYGLTEAIASSRALVKTRGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEHLAYSVPEILQFNLLGVPLVGADICGFQGNTTEELCVRWTQLGAFYPFMRNHNDLNSLPQEPYRFSETAQQAMRKAFTLRYALLPYLYTLFHGAHVKGDTVARPLFLEFPEDPSTWSVDRQLLWGPALLITPVLEPGKTDVTGYFPKGMWYNLQMVPVETLGSLPSSSPASSFRSIVHSKGQWLTLEAPLDTINVHLRAGYIIPLQGPSLTTTESRKQPMALAVALTESGEASGELFWDDGESLGVLERGAYTLVTFSAKNNTIVNKLVHVTKEGGELQLREVTILGVTTAPTQVLSNGISVSNFTYSPDDKSLSIPVSLLMGERFQIDWS
  
Inhibitor
Name:
BDBM50394348
Synonyms:
CHEMBL2159635
Type:
Small organic molecule
Emp. Form.:
C12H24O12S2
Mol. Mass.:
424.442
SMILES:
OC[C@H](O)[C@@H](O)[C@H](O)[C@@H](OS([O-])(=O)=O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Structure:
Search PDB for entries with ligand similarity: