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Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM50394611
Substrate
n/a
Meas. Tech.
ChEMBL_857730 (CHEMBL2168757)
EC50
>10000±n/a nM
Citation
 Chobanian, HR; Guo, Y; Liu, P; Chioda, M; Lanza, TJ; Chang, L; Kelly, TM; Kan, Y; Palyha, O; Guan, XM; Marsh, DJ; Metzger, JM; Gorski, JN; Raustad, K; Wang, SP; Strack, AM; Miller, R; Pang, J; Madeira, M; Lyons, K; Dragovic, J; Reitman, ML; Nargund, RP; Lin, LS Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett 3:252-256 (2012) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM50394611
Synonyms:
CHEMBL2164582
Type:
Small organic molecule
Emp. Form.:
C27H26F3N5O4S
Mol. Mass.:
573.587
SMILES:
C[C@H](O)c1nc(no1)-c1cccc2Nc3nc(ccc3CN(c12)S(=O)(=O)c1ccc(cc1)C(C)(C)C)C(F)(F)F |r|
Structure:
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