Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50395072
Substrate
n/a
Meas. Tech.
ChEMBL_859283 (CHEMBL2166571)
EC50
9.12±n/a nM
Citation
 Christiansen, E; Due-Hansen, ME; Urban, C; Grundmann, M; Schröder, R; Hudson, BD; Milligan, G; Cawthorne, MA; Kostenis, E; Kassack, MU; Ulven, T Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties. J Med Chem 55:6624-8 (2012) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50395072
Synonyms:
CHEMBL2164242
Type:
Small organic molecule
Emp. Form.:
C27H30FNO5S
Mol. Mass.:
499.594
SMILES:
Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(O)=O)c(F)c2)c1
Structure:
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