Reaction Details Report a problem with these data
Target
Probable G-protein coupled receptor 142
Ligand
BDBM50395789
Substrate
n/a
Meas. Tech.
ChEMBL_860250 (CHEMBL2169191)
EC50
2230±n/a nM
Citation
 Du, X; Kim, YJ; Lai, S; Chen, X; Lizarzaburu, M; Turcotte, S; Fu, Z; Liu, Q; Zhang, Y; Motani, A; Oda, K; Okuyama, R; Nara, F; Murakoshi, M; Fu, A; Reagan, JD; Fan, P; Xiong, Y; Shen, W; Li, L; Houze, J; Medina, JC Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes. Bioorg Med Chem Lett 22:6218-23 (2012) [PubMed]  Article 
Target
Name:
Probable G-protein coupled receptor 142
Synonyms:
G-protein coupled receptor PGR2 | GP142_HUMAN | GPR142 | PGR2
Type:
PROTEIN
Mol. Mass.:
51127.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_985961
Residue:
462
Sequence:
MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
  
Inhibitor
Name:
BDBM50395789
Synonyms:
CHEMBL2164845
Type:
Small organic molecule
Emp. Form.:
C24H25N5O3
Mol. Mass.:
431.487
SMILES:
O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NC[C@H]1CCC(=O)N1 |r|
Structure:
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