Reaction Details Report a problem with these data
Target
Cell division related protein kinase 2
Ligand
BDBM47658
Substrate
n/a
Meas. Tech.
ChEMBL_862287 (CHEMBL2173143)
IC50
1500±n/a nM
Citation
 Rotella, DP Recent results in protein kinase inhibition for tropical diseases. Bioorg Med Chem Lett 22:6788-93 (2012) [PubMed]  Article 
Target
Name:
Cell division related protein kinase 2
Synonyms:
CRK3 | Cdc2-related kinase | Cell division related protein kinase 2
Type:
PROTEIN
Mol. Mass.:
35647.04
Organism:
Leishmania major
Description:
ChEMBL_862288
Residue:
311
Sequence:
MSSFGRVTARSGDAGTRDSLDRYNRLDVLGEGTYGVVYRAVDKITGQYVALKKVRLDRTEEGIPQTALREVSILQEFDHPNIVNLLDVICSDGKLYLVFEYVEADLKKAIEKQEGGYSGMDLKRLIYQLLDGLYFCHRHRIIHRDLKPANILLTSGNVLKLADFGLARAFQVPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDMWSVGCIFAELTRRKVLFRGDSEIGQLFEIFQVLGTPTDTEGSWPGVSRLPDYRDVFPKWTAKRLGQVLPELHPDAIDLLSKMLKYDPRERISAKEALQHPWFSDLRW
  
Inhibitor
Name:
BDBM47658
Synonyms:
1-(4-methylphenyl)-3-(2-pyridin-3-ylpyrimidin-4-yl)urea | 1-(4-methylphenyl)-3-[2-(3-pyridinyl)-4-pyrimidinyl]urea | 1-(p-tolyl)-3-[2-(3-pyridyl)pyrimidin-4-yl]urea | MLS000706883 | N-(4-methylphenyl)-N'-[2-(3-pyridinyl)-4-pyrimidinyl]urea | SMR000335712 | cid_1477566
Type:
Small organic molecule
Emp. Form.:
C17H15N5O
Mol. Mass.:
305.3339
SMILES:
Cc1ccc(NC(=O)Nc2ccnc(n2)-c2cccnc2)cc1
Structure:
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