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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50397944
Substrate
n/a
Meas. Tech.
ChEMBL_873559 (CHEMBL2187476)
Ki
1.6±n/a nM
Citation
 Breining, SR; Melvin, M; Bhatti, BS; Byrd, GD; Kiser, MN; Hepler, CD; Hooker, DN; Zhang, J; Reynolds, LA; Benson, LR; Fedorov, NB; Sidach, SS; Mitchener, JP; Lucero, LM; Lukas, RJ; Whiteaker, P; Yohannes, D Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands. J Med Chem 55:9929-45 (2012) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50397944
Synonyms:
CHEMBL2177512
Type:
Small organic molecule
Emp. Form.:
C12H17N3
Mol. Mass.:
203.2835
SMILES:
C1NCC2CC1CN(C2)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: