Reaction Details Report a problem with these data
Target
4-aminobutyrate aminotransferase, mitochondrial
Ligand
BDBM50118886
Substrate
n/a
Meas. Tech.
ChEMBL_884621 (CHEMBL2214168)
Ki
10000000±n/a nM
Citation
 Pan, Y; Gerasimov, MR; Kvist, T; Wellendorph, P; Madsen, KK; Pera, E; Lee, H; Schousboe, A; Chebib, M; Bräuner-Osborne, H; Craft, CM; Brodie, JD; Schiffer, WK; Dewey, SL; Miller, SR; Silverman, RB (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent¿-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction. J Med Chem 55:357-66 (2012) [PubMed]  Article 
Target
Name:
4-aminobutyrate aminotransferase, mitochondrial
Synonyms:
Abat | GABT_RAT | Gabat | Gamma-amino-N-butyrate transaminase
Type:
PROTEIN
Mol. Mass.:
56465.74
Organism:
Rattus norvegicus
Description:
ChEMBL_884621
Residue:
500
Sequence:
MAFLLTTRRLVCSSQKNLHLFTPGSRYISQAAAKVDFEFDYDGPLMKTEVPGPRSQELMKQLNTIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYNHPALAKLVQQPQNASTFINRPALGILPPENFVDKLRESLMSVAPKGMCQLITMACGSCSNENAFKTIFMWYRSKERGQRGFSKEELETCMVNQSPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVTDNQQEEARCLEEVEDLIVKYRKKKRTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMSFSKKMMTGGFFHKEEFRPSAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNVAHAGKTLLTGLLDLQAQYPQFVSRVRGRGTFCSFDTPDEAIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSGILADFK
  
Inhibitor
Name:
BDBM50118886
Synonyms:
4-Amino-hex-5-enoic acid | CHEMBL89598 | US10189807, (S)-vigabatrin | VIGABATRIN
Type:
Small organic molecule
Emp. Form.:
C6H11NO2
Mol. Mass.:
129.157
SMILES:
NC(CCC(O)=O)C=C
Structure:
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